Neulyn: Each film-coated Sustained Release Tablet contains Theophylline BP 400 mg.
Theophylline is a bronchodilator, structurally classified as a Methylxanthine. Theophylline relaxes bronchial smooth muscle, relieves bronchospasm, and has a stimulant effect on respiration. It stimulates the myocardium and CNS, decreases peripheral resistance and venous pressure, and causes diuresis.
Dosage & Administration
Neulyn is used to control of acute asthma, management of chronic asthma (both symptomatic and prophylactic treatment), controlling of nocturnal asthma and early morning wheezing and to control of apnea of pre-maturity.
Adult: 1 tablet 12 hourly or as directed by the physicians.
Neulyn is contraindicated to any known hypersensitivity to xanthine derivatives. It is also contraindicated in patients with active peptic ulcer diseases and in individuals with underlying seizure disorders (unless receiving appropriate anti-convulsing medication).
Theophylline should be given with caution to patients with hyperthyroidism, viral infection, congestive heart failure, hypertension, cardiac arrhythmias or other cardiovascular diseases, or epilepsy, as these conditions may be exacerbated. They should also be given with caution to patients with heart failure, hepatic dysfunction, chronic alcoholism, acute febrile illness, since in all of these circumstances theophylline clearance may be decreased, resulting in increases in serum-theophylline concentrations and serum half-life. Conversely, smoking increases theophylline clearance.
Use Pregnancy Lactation
Safety in human pregnancy has not been established. Theophylline crosses the placental barrier & is secreted in breast milk. Theophylline should be used with caution in pregnancy & lactation.
Theophylline clearance may be reduced by interaction with other drugs including allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferonalfa, macrolide antibacterials and quinolones, oral contraceptives, and the dose may need to be reduced. Phenytoin and some other antiepileptics, ritonavir, rifampicin, and sulfinpyrazone may increase theophylline clearance, and require an increase in dose or dosing frequency.
Theophylline may cause nausea, vomiting, abdominal pain, diarrhoea, gastrooesophageal reflux, and other gastrointestinal disturbances, insomnia, headache, anxiety, restlessness, dizziness, tremor, and palpitations. Overdosage may also lead to agitation, diuresis and repeated vomiting (sometimes haematemesis) and consequent dehydration, cardiac arrhythmias including tachycardia, hypotension, and electrolyte disturbances including profound hypokalaemia, hyperglycaemia, metabolic acidosis, convulsions, and death. Convulsions, cardiac arrhythmias, and hypotension may follow intravenous injection, particularly if the injection is too rapid, and sudden deaths have been reported; the drug is too irritating for intramuscular use.
Store in a cool and dry place, away from direct light. Keep out of the reach of the children.
Each box contains 10X10\'s tablets in blister pack.