Clognil Plus: Each film-coated Clognil Plus tablet contains Clopidogrel INN 75 mg and Aspirin USP 75 mg.
Clognil Plus is indicated for the prevention of ischemic events, myocardial infarction, stroke and cardiovascular death in patients with acute coronary syndrome.
Hypersensitivity to Clopidogrel
Hypersensitivity to Aspirin and/or non-steroidal anti-inflammatory agents
Recent history of gastrointestinal bleeding
Active pathological bleeding such as peptic ulcer or intracranial hemorrhage, or bleeding disorders like hemophilia
Dosage & Administration
The recommended dose is one tablet once daily.
PregnancyAdverse effects are increased in the mother and the foetus followingchronic ingestion of Aspirin. Because of possible adverse effects on theneonate and the potential for increased maternal blood loss, Clognil Plusshould be avoided during the last three months of pregnancy.Nursing mothersClognil Plus should be avoided in nursing mothers because of the possiblerisk of developing Reye\\\'s syndrome. Regular use of high doses of Aspirincould impair platelet function and produce hypoprothrombinemia ininfants if neonatal vitamin K levels are low.Pediatric useSafety and effectiveness of Clognil Plus in the pediatric population havenot been established.Adverse reactionsThe drug is generally well tolerated. Side effects that have been reportedinclude abdominal pain, dyspepsia, gastritis, diarrhea, nausea, vomiting,constipation, gastrointestinal hemorrhage, ulceration, neutropenia, rash,palpitation, syncope, drowsiness, asthenia, neuralgia, paresthesia andvertigo.
As with other antiplatelet agents, Clopidogrel should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. If a patient is to undergo elective surgery and an antiplatelet effect is not desired, Clopidogrel should be discontinued 7 days prior to surgery.
Hepatic or Renal Impairment
Should be avoided in patients with impaired hepatic and renal function.
Aspirin causes sodium and water retention in patients with renal impairment and increases the risk of gastrointestinal bleeding.
This combination may enhance the effect of anticoagulants.
Clognil Plus: Each box contains 3x10 tablets in alu-alu blister pack.