Preparation
Clognil Plus: Each film-coated Clognil Plus tablet contains Clopidogrel INN 75 mg and Aspirin USP 75 mg.
Indication
Clognil Plus is indicated for the prevention of ischemic events, myocardial infarction, stroke and cardiovascular death in patients with acute coronary syndrome.
Dosage & Administration
The recommended dose is one tablet once daily.
Side Effect
PregnancyAdverse effects are increased in the mother and the foetus followingchronic ingestion of Aspirin. Because of possible adverse effects on theneonate and the potential for increased maternal blood loss, Clognil Plusshould be avoided during the last three months of pregnancy.Nursing mothersClognil Plus should be avoided in nursing mothers because of the possiblerisk of developing Reye\\\'s syndrome. Regular use of high doses of Aspirincould impair platelet function and produce hypoprothrombinemia ininfants if neonatal vitamin K levels are low.Pediatric useSafety and effectiveness of Clognil Plus in the pediatric population havenot been established.Adverse reactionsThe drug is generally well tolerated. Side effects that have been reportedinclude abdominal pain, dyspepsia, gastritis, diarrhea, nausea, vomiting,constipation, gastrointestinal hemorrhage, ulceration, neutropenia, rash,palpitation, syncope, drowsiness, asthenia, neuralgia, paresthesia andvertigo.
Precaution
General
As with other antiplatelet agents, Clopidogrel should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. If a patient is to undergo elective surgery and an antiplatelet effect is not desired, Clopidogrel should be discontinued 7 days prior to surgery.
Hepatic or Renal Impairment
Should be avoided in patients with impaired hepatic and renal function.
Aspirin causes sodium and water retention in patients with renal impairment and increases the risk of gastrointestinal bleeding.
Drug Interaction
This combination may enhance the effect of anticoagulants.
Presentation
Clognil Plus: Each box contains 3x10 tablets in alu-alu blister pack.
