Preparation
Orlev 250 Tab: Each tablet contains Levofloxacin INN 250 mg (as Levofloxacin Hemihydrate).
Orlev 500 Tab: Each tablet contains Levofloxacin INN 500 mg (as Levofloxacin Hemihydrate).
Therapeutic Class
Fluroquinolone Antibiotic
Indication
Levofloxacin (Orlev) is indicated for the infections caused by susceptible organisms such as:
Respiratory tract infections
Acute maxillary sinusitis, caused by susceptible Haemophilus influenzae, Moraxella (Branhamella) catarrhalis or Streptococcus pneumoniae. Acute exacerbation of chronic bronchitis, caused by susceptible H. influenzae, H. parainfluenzae, M. catarrhalis, Staphylococcus aureus.
Community-acquired pneumonia, caused by susceptible S. pneumoniae, (including penicillin resistant strains), S. aureus, H. influenzae, H. parainfluenzae, K. pneumoniae, Legionella pneumoniae, M. catarrhalis and M. pneumoniae.
Skin and skin structure infections
Levofloxacin (Orlev) is used in adult for the treatment of both uncomplicated and complicated skin and skin structure infections caused by susceptible S. aureus, Enterococcus faecalis, S. pyogenes or Proteus mirabilis.
Urinary tract infections
Levofloxacin (Orlev) can be used for the treatment of both uncomplicated and complicated urinary tract infections caused by susceptible E. coli, K. pneumoniae, S. saprophyticus, Enterobacter cloacae or Enterococcus faecalis.
Contraindication
Levofloxacin (Orlev) is contraindicated in patients with known hypersensitivity to Levofloxacin or quinolone group of antibiotics.
Dosage & Administration
In acute sinusitis: 500 mg daily for 10-14 days.
In exacerbation of chronic bronchitis: 250-500 mg daily 7-10 days.
In community-acquired pneumonia: 500 mg once or twice daily 7-14 days.
In complicated urinary tract infections: 250 mg daily 7-10 days.
In skin and skin structure infections: 250 mg daily or 500 mg once or twice daily for 7-14 days.
Side Effect
Levofloxacin is generally well tolerated, but side effects like GI disturbance includes nausea, vomiting, diarrhea, abdominal pain and dyspepsia, skin rash, headache, dizziness, restlessness, insomnia, nightmares and more rarely hallucination, convulsion, depression, psychotic reaction may occur.
Precaution
Dosage adjustment of Levofloxacin is required in patients with renal insufficiency. Levofloxacin should not be used in children, adolescent, pregnant women or breast feeding mothers.
Drug Interaction
Antacids containing magnesium or aluminium, sucralfate, metal cations such as iron or zinc may interfere with oral absorption of Levofloxacin.
Presentation
Orlev 250 Tablet: Box containing 2 x 10\'s tablets in blister pack.
Orlev 500 Tablet: Box containing 2 x 10\'s tablets in blister pack.
