Zinc has been shown to be a vital constituent of more than 90 metalloenzymes. Zinc
deficient cells fail to divide and differentiate, with consequent growth impairment.
Zinc is essential for normal embryonic development. Deficiency results in
malformations of brain, eyes, bones, heart and other organs. The survival of the
embryo is placed at risk when zinc intake is reduced even for a period of days,
particularly in the first trimester. There is a decline of plasma zinc during the first
trimester, which continues throughout pregnancy.
Folic acid is the biologically active coenzyme, tetrahydrofolic acid, which is important
in the biosynthesis of amino acids and DNA and therefore in cell division. There is an
incidence of prematurity and low birth weight infants in folate deficient women,
which is preventable by folate supplement. The incidence of neural tube defects in the
newborn may be reduced by folate supplements to the mother at conception.

ESP capsule is a combination of blended pellets of Zinc sulphate monohydrate USP 61.8
mg equivalent to 22.5 mg of elemental Zinc and Folic acid BP 500 mcg.

ESP is indicated for prophylaxis of Zinc and Folic acid deficiency, specially during the
first trimester of pregnancy.

One capsule daily throughout the first trimester of pregnancy

Zinc is contraindicated in patients having hypersensitivity to zinc. Folic acid is
contraindicated in untreated cobalamine deficiency

Large amounts of Ca decrease the absorption of zinc. In case of Folic acid, no drug
interaction have been reported.

Zinc may cause gastric ulcer, lethargy, fever, mild abdominal pain and dyspepsia etc.
In case of folic acid, allergy occurs rarely and epilepticus may be precipitated.

Box containing 3 X 10\'s capsules in blister pack.

Store in a cool, dry place and away from direct sunlight. Keep all medicines out of the
reach of children.