Preparation
Each coated tablet contains Flupentixol dihydrochloride corresponding to 0.5 mg Flupentixol and Melitracen hydrochloride corresponding to 10 mg Melitracen.
Therapeutic Class
Anxiolytic & Antidepressant
Indication
In various types of anxiety, depression & apathy. These include-
- Psychogenic depression
- Depressive neuroses
- Masked depression
- Psychosomatic affections accompanied by anxiety and apathy
- Menopausal depressions
- Dysphoria and depression in alcoholics and drug-addicts
Contraindication
The immediate recovery phase after myocardial infarction. Defects in bundle-branch conduction. Untreated narrow angle glaucoma. Acute alcohol, barbiturate and opiate intoxications. Flupentixol-Melitracen should not be given to patients who received a MAO-inhibitor within two weeks. Not recommended for excitable or overactive patients since its activating effect may lead to exaggeration of these characteristics.
Dosage & Administration
Adults: Usually 2 tablets daily: Morning and noon.
In severe cases the morning dose may be increased to 2 tablets.
Elderly patients: 1 tablet in the morning.
Maintenance dose: usually 1 tablet in the morning.
In cases of insomnia or severe restlessness additional treatment with a sedative in the acute phase is recommended.
Side Effect
In the recommended doses side effects are rare. These could be transient restlessness and insomnia.
Precaution
If previously the patient has been treated with tranquillizers with sedative effect these should be withdrawn gradually.
Flupentixol-Melitracen should preferably not be given during pregnancy and lactation.
Drug Interaction
Flupentixol and Melitracen may enhance the response to barbiturates and other CNS depressants. Simultaneous administration of MAO-inhibitors may cause hypertensive crises. Neuroleptics and thymoleptics reduce the antihypertensive effect of guanethidine and similar acting compounds and thymoleptics enhance the effects of adrenaline and noradrenaline.
Presentation
Each box containing 5X10 tablets tablets in blister pack.