Bisoloc-2.5: Each film-coated tablet contains Bisoprolol Fumarate USP 2.5 mg.
Bisoloc-5: Each film-coated tablet contains Bisoprolol Fumarate USP 5 mg.
Bisoloc-2.5 & Bisoloc-5 are indicated in the management of hypertension and in the treatment of angina. It may be used alone or in combination with other antihypertensive agents.
Bisoprolol is contraindicated in patients with cardiogenic shock, overt cardiac failure, second or third degree AV block, and marked sinus bradycardia.
The dose of Bisoloc must be individualized to the needs of the patient. The usual starting dose is 5 mg once daily. In some patients, 2.5 mg may be an appropriate starting dose. If the antihypertensive effect of 5 mg is inadequate, the dose may be increased to 10 mg and then, if necessary, to 20 mg once daily.
Patients with Renal or Hepatic Impairment: In patients with hepatic impairment (hepatitis or cirrhosis) or renal dysfunction (creatinine clearance <40 mL/min), the initial daily dose should be 2.5 mg.
Dosage & Administration
Fatigue, dizziness, headache, nausea, vomiting, diarrhoea, constipation or abdominal pain, cold or numb extremities, e.g. hands and feet, muscle weakness or cramps, bradycardia, worsening of heart failure, sleep disturbance, depression, breathing difficulties due to a narrowing of the airways (bronchospasm) in people with asthma or COPD.
Use caution in adjusting the dose of Bisoprolol in patients with renal or hepatic impairment. Bisoprolol should be avoided if the patient is hypersensitive to it.
Bisoprolol should not be used during pregnancy unless clearly necessary. If treatment with Bisoprolol is considered necessary, the uteroplacental blood flow and the foetal growth should be monitored. In case of harmful effects, alternative treatment should be considered.
Bisoprolol should not be used with the following medications because of very serious, possibly fatal interactions may occur:- Certain blood-pressure lowering drugs (clonidine, methyldopa or moxonidine)
- Calcium-channel blockers (verapamil or diltiazem).
Bisoloc-2.5: Each box contains 3X10 tablets in blister pack.
Bisoloc- 5: Each box contains 3X10 tablets in blister pack.