Preparation
Frulac: Each tablet contains Frusemide BP 20 mg and Spironolactone BP 50 mg.
Frulac-40: Each tablet contains Frusemide BP 40 mg and Spironolactone BP 50 mg.
Indication
Frulac: Congestive heart failure, essential hypertension, liver cirrhosis with ascites, edema, hyperaldosteronism.
Frulac-40: Indicated for previously stabilized patients requiring higher dosage of Spironolactone and Frusemide.
Contraindication
Frulac and Frulac-40 are contraindicated in acute renal insufficiency, anuria, hyperkalemia and in patients with a history of hypersensitivity to Frusemide or Spironolactone.
Dosage & Administration
Frulac: 1 to 4 tablets daily (50 to 200 mg of Spironolactone and 20 to 80 mg of Frusemide) according to the patient\'s response.
Frulac-40: 1 to 2 tablets daily (50 to 100 mg of Spironolactone and 40 to 80 mg of Frusemide) according to the patient\'s response.
Side Effect
Common side effects that are known to be associated with Frulac and Frulac-40 are fatigue, blood disorders, skin rashes, cramping, diarrhea, constipation, nausea, pancreatitis, jaundice, anorexia, vasculitis, tinnitus, loss of hearing, vertigo, dizziness, paresthesiasis, vomiting or abdominal pain, hyperglycemia, hypotension, gynecomastia, irregular menstrual cycle, disturbances in the levels of electrolytes in the blood, impotence.
Precaution
It is recommended that individuals taking this medicine have their fluid and electrolyte balance monitored regularly. Frulac and Frulac-40 should be used with caution in diabetes, prostatic hypertrophy, hypotension, hypovolemia.
Drug Interaction
When Frulac or Frulac-40 is taken together with ACE inhibitors or potassium salts there is an increased risk of hyperkalemia. Spironolactone increases the levels of cardiac glycosides such as digoxin in the blood. Corticosteroids may also cause potassium loss and severe depletion may occur if they are used with Frusemide. When taken together with drugs that decrease blood pressure there is an increased risk of a large drop in blood pressure and fainting. The blood pressure lowering and diuretic effects of Frusemide may be reduced or abolished when used together with indomethacin and possibly other non-steroidal anti-inflammatory drugs (NSAIDs).
Presentation
Frulac: Box containing 5X10 tablets in blister pack.Frulac-40: Box containing 3X10 tablets in blister pack.
