Preparation
Each film coated tablet contains Moxifloxacin Hydrochloride BP equivalent to Moxifloxacin 400 mg.
Indication
Moxifloxacin is indicated for the treatment of adults (>18 years of age) with infections caused by susceptible strains of the designated microorganisms in the conditions listed below-
-Acute Bacterial Sinusitis caused by Streptococcus pneumoniae, Haemophilus influenzae or Moraxella catarrhalis
-Acute Bacterial Exacerbation of Chronic Bronchitis caused by streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, methicillin-susceptible Staphylococcus aureus or Moraxella catarrhalis
-Community Acquired Pneumonia caused by Streptococcus pneumoniae (including multi-drug resistant strains), Haemophilus influenzae, Moraxella catarrhalis, methicillin-susceptible Staphylococcus aureus, Klebsiella pneumoniae, Mycoplasma pneumoniae or Chlamydophilia pneumoniae
-Uncomplicated Skin and Skin Structure Infections caused by methicillin-susceptible Staphylococcus aureus or Streptococcus pyogenes
-Complicated Skin and Skin Structure Infections caused by methicillin-susceptible Staphylococcus aureus, E. coli, Klebsiella pneumoniae or Enterobacter cloacae
-Complicated Intra-Abdominal Infections including polymicrobial infections such as abscess caused by E. coli, Bacteroides fragilis, Streptococcus anginosus, Streptococcus constellatus, Enterococcus faecalis, Proteus mirabilis, Clostridium perfringens, Bacteroides thetaiotaomicron or Peptostreptococcus species.
Contraindication
Moxifloxacin is contraindicated in persons with a history of hypersensitivity to Moxifloxacin or any member of the quinolone class of antimicrobial agents and any component of this formulation.
Side Effect
The following one or more side effects may be observed: tendinopathy, QT prolongation, hypersensitivity reactions, Clostridium difficile-associated diarrhea, peripheral neuropathy, photosensitivity etc.
Precaution
Moxifloxacin should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity. Moxifloxacin should be discontinued if the patient experiences pain, swelling, inflammation or rupture of a tendon.
Drug Interaction
No quinolone should be co-administered with any solution containing multivalent cations (e.g.manesium) through the same intravenous line. Antacids, iron and adsorbents reduce absorption of Moxifloxacin. NSAID may increase the risk of CNS stimulation. Warfarin may increase the risk of bleeding.
Use Children
Efficacy and safety of Moxifloxacin tablet in children and adolescent have not been established.
Use Pregnancy Lactation
USFDA Pregnancy Category-C. Moxifloxacin is not recommended during pregnancy & lactation.
Overdosage
In the events of an acute overdosage, the stomach should be emptied. The patients should be kept under observation and appropriate hydration should be maintained.
Packaging
Each box contains 2 Alu-Alu blister strips each of 5 tablets.
Storage
Store in a cool, dry place, protected from light. Store below 30 oC. Keep all medicines out of the reach of children.
