Preparation
Ckemia 2 Tablet: Each film-coated tablet contains 2 mg Daprodustat INN.
Ckemia 4 Tablet: Each film-coated tablet contains 4 mg Daprodustat INN.
Indication
Ckemia is indicated for the treatment of anemia due to chronic kidney disease (CKD) in adults who have been receiving dialysis for at least four months.
Contraindication
Daprodustat is contraindicated in patients receiving a strong CYP2C8 inhibitor such as Gemfibrozil & with uncontrolled hypertension.
Dosage & Administration
Starting dose of Ckemia for adults receiving dialysis for at least 4 months with anemia due to chronic kidney disease and not receiving an erythropoiesis-stimulating agent.
| Pre-Treatment Hemoglobin Level (g/dl) |
Starting Dose of Ckemia (Once Daily Dosing) |
| <9 |
4 mg |
| ≥9 to ≤ |
2 mg |
| |
1 mg |
Starting dose of Ckemia for adults on dialysis switching from an erythropoiesis-stimulating agent.
|
Dose of Erythropoiesis – Stimulating Agent
|
Dose of Ckemia (Once Daily Dosing)
|
|
Epoetin Alfa Intravenous (units/week)
|
Darbepoetin Alfa Subcutaneous/Intravenous
(mcg/4 weeks)
|
Methoxy PEG-Epoetin Beta Subcutaneous/Intravenous
(mcg/month)
|
|
Less than or equal to 2,000
|
20 to 30
|
30 to 40
|
4 mg
|
|
Greater than 2,000 to less than 10,000
|
Greater than 30 to 150
|
Greater than 40 to 180
|
6 mg
|
|
Greater than or equal to 10,000 to less than 20,000
|
Greater than 150 to 300
|
Greater than 180 to 360
|
8 mg
|
|
Greater than or equal to 20,000
|
Greater than 300
|
Greater than 360
|
12 mg
|
Side Effect
Increased risk of heart attack, stroke, and blood clots.
Precaution
Increased risk of death, myocardial infarction, stroke, venous thromboembolism, hypertension and thrombosis of vascular access.
Drug Interaction
CYP2C8 inhibitors (Gemfibrozil, Clopidogrel), CYP2C8 inducers (Rifampin).
Use Children
Pediatrics
Safety and effectiveness of Daprodustat in pediatric patients have not been established.
Use Pregnancy Lactation
Pregnant women:
Not recommended for use in pregnant women, may cause fetal harm.
Lactating women:
Breastfeeding is not recommended until one week after the final dose.
Overdosage
Headache and gastrointestinal adverse reactions (e.g.nausea) may be seen with acute overdose with Daprodustat.
Packaging
Ckemia 2 Tablet: Each box contains 1X10’s tablets in alu-alu blister pack.
Ckemia 4 Tablet: Each box contains 1X10’s tablets in alu-alu blister pack.
Storage
Store below 30 ºC. Protect from light and moisture. Keep all medicines out of the reach of children.
